pentobarbital will reduce the extent or impact of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers lowers plasma concentration of abemaciclib and its metabolites.pentobarbital will minimize the extent or outcome of buprenorphine, l